Объединенная инфекция CMV с EBV или HHV-6

Если у вас язвенный колит, а также присутствуют объединённые вирусы ЦМВ, ВЭБ и Герпесовирусная инфекция 6-го типа (ГВИ 6-го типа), одновременно 2 из них, то это плохие новости: 

Объединенная инфекция CMV с EBV или HHV-6 была значительным и независимым прогностическим фактором для последующей колэктомии у больных с язвенным колитом.

 

Combined Infection of Human Herpes Viruses: A Risk Factor for Subsequent Colectomy in Ulcerative Colitis.

Hosomi S, et al. Inflamm Bowel Dis. 2018.

Authors

Author information

1
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
2
Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Hyogo, Japan.
3
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Citation

Inflamm Bowel Dis. 2018 May 18;24(6):1307-1315. doi: 10.1093/ibd/izy005.

Abstract

Background: Little is known about the prevalence and pathogenicity of human herpes viruses except for cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of human herpes viruses on colonic mucosa in patients with IBD and assess the long-term outcomes in these patients.

Methods: 

We examined the colonic mucosal specimens from 66 patients with ulcerative colitis (UC), 54 patients with Crohn’s disease (CD), and 29 healthy patients to identify the 6 most common types of human herpes virus, using multiplex polymerase chain reaction (PCR) technique.

Results: 

Herpes simplex virus (HSV)-1/2 and varicella-zoster virus (VZV) were not detected in any of the groups. There was a higher prevalence of Epstein-Barr virus (EBV) (21.2%) and CMV (15.1%) in patients with UC than in patients with CD (EBV 9.3%, CMV 0%) and patents in the healthy control group (EBV 0%, CMV 3.4%). The prevalence of human herpes virus (HHV)-6A/B and HHV-7 was not statistically different among the groups. Five UC patients with inflammation had coexisting CMV and EBV or HHV-6. The combined infection of CMV with EBV or HHV-6 was a significant and independent prognostic factor for subsequent colectomy in patients with UC.

Conclusions: 

The increased prevalence of CMV coexisting with EBV/HHV-6 infection was associated with the clinical course in patients with UC.

10.1093/ibd/izy005_video1izy005_Video_15786489376001.

PMID 29668948 [ — in process]

Inflammatory Bowel Diseases, Volume 24, Issue 6, 18 May 2018, Pages 1307–1315,https://doi.org/10.1093/ibd/izy005
Published:
13 April 2018

ORIG